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InChiKey: AMBQHHVBBHTQBF-CBQOGAMZSA-N
Chemical Name: 4-(1-methyl-1H-pyrazol-5-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1
Smiles: CC(C)CC(=O)O[C@@H]1[C@@H](CCCCCC)C(=O)O[C@H](C)[C@H](NC(=O)C2=CC=CC(NC=O)=C2O)C(=O)O[C@H]1C
Kudlinzki D
AZD3839 CB19 InChiKey: AMBQHHVBBHTQBF-CBQOGAMZSA-NAZD3839 is a novel inhibitor of BACE1 with IC50 value of 4. 8M . AZD3839 has been reported to inhibit human BACE1 activity in a biochemical FRET assay. In addition, AZD3839 has also been reported to inhibit the release of sAPPs from human SH SY5Y cells, mouse N2A cells and mouse and guinea pig primary cortical neurons. Moreover, AZD3839 has been revealed to effectively decrease the cerebrospinal fluid (CSF), plasma, and brain A levels in guinea pig,
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