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PMID: 30429129
a serine/threonine kinase that regulates critical mitotic events
PubMed Central PMCID: PMC3263969
Solubility: DMSO: 47 mg/mL(198
A-966492 Size:2mg solid PMID: 30429129A 966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP 1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A 966492 is orally bioavailable across multiple species, crosses the blood brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX 1 breast
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