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AP20187-mediated activation of a chimeric insulin receptor results in insulin-like actions in skeletal muscle and liver of diabetic mice
Smiles: CC1=NC(N)=NC2=C1C=C(C(=O)N2C1CCC(CC1)OCCO)C1=CN=C(C=C1)OC
J Antibiot (Tokyo)
1051/medsci/20132910007
Eltrombopag (Olamine) Size:Solid 2 mg AP20187-mediated activation of a chimericEltrombopag is a small molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Eltrombopag was
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