TCS 2002 iclopirox 15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate

15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate

dimerization

Chemical Name: 3-({4-hydroxy-1-[(3R

It was dosed to diabetic ob/ob mice via oral gavage at 3-30 mg/kg once per day for 2 weeks

TCS 2002 iclopirox 15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetateTCS 2002 is a potent inhibitor of GSK 3 with IC50 value of 35 nM . Glycogen synthase kinase 3 (GSK 3) is a serine threonine protein kinase and functions by phosphorylating a serine or threonine residue on its target protein. GSK3 plays an important role in neuronal cell development, energy metabolism and body pattern formation. TCS 2002 is a potent GSK 3 inhibitor with IC50 value of 35 nM. (S) TCS 2002 and (R) TCS 2002 inhibited GSK 3 with IC50 values