Ro 25-6981 Size:Solid 2 mg 21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16

21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16

Rolapitant reverses NK1 agonist-induced foot tapping in gerbils following both intravenous and oral administration up to 24 hours at a minimal effective dose (MED) of 0

37 mM) Ethanol 20 mg/mL (43

(2013) Nat Cell Biol

Ro 25-6981 Size:Solid 2 mg 21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16Ro 25 6981 is a highly potent and selective blocker of N methyl D aspartate receptors containing the NR2B subunit. Ro 25 6981 inhibited 3H MK 801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0. 003 microM and 149 microM for high (about 60%) and low affinity sites, respectively. NMDA receptor subtypes expressed in Xenopus oocytes were blocked with IC50 values of 0. 009 microM and 52 microM for the subunit combinations