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4 nM for rodent GPR39
Within days of treatment
ROC-325 antagonized RCC growth and survival in an ATG5/7-dependent manner
G401 and NS cell lines in a concentration-dependent manner
Torin 1 - CAS# 1222998-36-8 Catalog No.:M6633-2 4 nM for rodent GPR39Torin 1, CAS No. 1222998 36 8, is a potent and selective mTOR inhibitor. The apoptosis inducing mTOR inhibitor Torin 1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin 1 also affected the expression of markers for cell proliferation, angio lympho genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44. Importantly,
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