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apolipoprotein B
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
2014 Nov 10
It is well absorbed with absolute oral bioavailability between 80 and 100%
MAK-683 - CAS# 1951408-58-4 Catalog No.:M7137-2 apolipoprotein BMAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED
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