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KAN 0438757
Epub 2017 Jan 24
TH588 was dosed to the mice by subcutaneous administration at 30 mg/kg once per day for 21 days
57 nmol/L)
SGI-110 Size:Solid 10 mg KAN 0438757Guadecitabine, aslo known as SGI 110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI 110 inhibits DNA methyltransferase, thereby causing genome wide and non specific hypomethylation and inducing cell cycle arrest at S phase. This agent is resistant to cytidine deaminase, hence may
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