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PubMed PMID: 25381820
2173992-60-2
Smiles: O=C1NC2=CC=C(Cl)C=C2C(N[C@@H]2C[N@]3CC[C@@H]2CC3)=C1C1NC2=CC=CC=C2N=1
(2015) Nat Biotechnol
WEHI-345 - CAS# 1354825-58-3 size:10mg solid PubMed PMID: 25381820WEHI 345, CAS No. 1354825 58 3, is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI 345 delays RIPK2 ubiquitylation and NF B activation downstream of NOD engagement. Despite only delaying NF B activation on NOD stimulation, WEHI 345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice. Product information CAS
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