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PubMed PMID: 17962474
NICE guidance on eluxadoline for treating irritable bowel syndrome with diarrhoea
Smiles: OC[C@@H]1CC[C@@H](O1)N1C=NC2C(=O)N=CNC1=2
6)17-23(18-31(37
EBE-A22 Catalog No.:M10416-10 PubMed PMID: 17962474EBE A22 is a derivative of PD 153035. EBE A22, has no effect on EGF R TK but maintains a high cytotoxic profile. EBE A22 binds to DNA and behave as typical intercalating agents. EBE A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE A22, but not PD153035, interacts preferentially with GC rich sequences and discriminates against