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and consequently
with potential antineoplastic activity
19(3):297-312
It is also a potent anticonvulsant in animal tests
PP2 - CAS# 172889-27-9 Catalog No.:M9704-10 and consequentlyPP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP 70 (100 M) and JAK2 (50 M). Despite its extensive use as a Src selective inhibitor, recent research has shown that PP2 is non selective and inhibits many
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