SU14813 maleate - CAS# 849643-15-8 Size:Solid 10 mg OTS964 hydrochloride (intravenously

OTS964 hydrochloride (intravenously

3800 and 6000 nM for MET

It has minimal inhibition of UCHL-1

2014 Mar 18

SU14813 maleate - CAS# 849643-15-8 Size:Solid 10 mg OTS964 hydrochloride (intravenouslySU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet derived growth factor receptors (PDGFR), KIT, and fms like tyrosine kinase 3 (FLT 3) (1). SU14813 was developed as a next generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. SU14813 demonstrated broad and potent antitumor activity