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780 and 1940 nM for ROCK1
7 μM for inhibition of lipolysis in vitro
8mg/mL in DMSO
Probe Reports from the NIH Molecular Libraries Program
DMH-1 - CAS# 1206711-16-1 60251 780 and 1940 nM forDMH 1, CAS No. 1206711 16 1, is a second generation small molecule BMP inhibitor based on dorsomorphin. DMH 1 effectively inhibits the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Treatment with DMH1 reduced lung metastasis and the tumors were less proliferative and more apoptotic. In the surrounding tumor microenvironment, treatment with DMH1 altered fibroblasts, lymphatic vessels and macrophages to be less tumor promoting. These
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