ZJ 43 60075 9 nM and 3nM

9 nM and 3nM

Formula: C13H17NaO2

Chemical Name: {2-[(3-aminopropyl)amino]-1-sulfanylethoxy}phosphonic acid trihydrate

6-²H₈)piperazin-1-yl]propyl}-10H-phenothiazine

ZJ 43 60075 9 nM and 3nMIC50: 2. 4 nM ZJ 43 is a N acetylaspartylglutamate (NAAG) peptidase inhibitor. The peptide neurotransmitter N acetylaspartylglutamate (NAAG) is reported to act as an agonist at group II metabotropic glutamate receptors. NAAG is inactivated by extracellular peptidase activity leading to yielding glutamate and N acetylaspartate. In vitro: As a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III) with Kivalues of 0. 8 and 23 nM