SPD304 dihydrochloride tractylenolide III 5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2

5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2

WO2019195665A1

WO 2008040934 A1 20080410

15(10):1465-73

SPD304 dihydrochloride tractylenolide III 5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2SPD304 dihydrochloride is a selective TNF inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 M for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF . Product information CAS Number: 1049741 03 8 Molecular Weight: 620. 53 Formula: C32H34Cl2F3N3O2 Chemical Name: 6, 7 dimethyl 3 {[methyl({2 [methyl({1 [3 (trifluoromethyl)phenyl] 1H indol 3