Fosbretabulin (disodium) - CAS# 168555-66-6 od Hydrochloride CAS Number: 182431-12-5

CAS Number: 182431-12-5

InChi: InChI=1S/C29H36O15/c1-13-22(35)24(37)25(38)29(42-13)44-27-23(36)20(12-41-21(34)7-4-14-2-5-16(30)18(32)10-14)43-28(26(27)39)40-9-8-15-3-6-17(31)19(33)11-15/h2-7

PD-123319 TFA

decreases release of pro-inflammatory cytokines

Fosbretabulin (disodium) - CAS# 168555-66-6 od Hydrochloride CAS Number: 182431-12-5Fosbretabulin disodium is the disodium salt of a water soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule