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INCB053914 phosphate inhibits proliferation in all multiple myeloma (MM) cell lines tested
treatment with up to 5 mg/kg Cobimetinib (GDC-0973) lead to moderate TGI and at 10 mg/kg approaches tumor stasis
87% at the dose of 25
Smiles: CC(=C)C(=O)O[C@H](C)[C@H]1[C@@H](O)C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@H](O)C[C@]4(C)[C@H]3CC[C@@]21C
ML-SI3 hyl)anthraquinone INCB053914 phosphate inhibits proliferation inML SI3 is a chemical compound which acts as an "antagonist" (i. e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Product information CAS Number: 891016 02 7 Molecular Weight: 429. 58 Formula:
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