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In female rats a single oral dose (10 mg/kg) achieves similar drug levels as a single intravenous injection (5 mg/kg) with regard to Cmax
H358 and H460 cells (at 72 hours)
Teschemacher AG
Epub 2016 Sep 28
PROTAC AR Degrader-4 TFA liquiritigenin In female rats a singlePROTAC AR Degrader 4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader 4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non genetic IAP dependent protein erasers (SNIPERs) Product information Molecular Weight: 884. 03 Formula: C45H68F3N3O11 Chemical Name: (1S,3aS,3bR,5aS,9aS,9bS,11aS) 9a,11a dimethyl 7 oxo hexadecahydro 1H cyclopenta[a]phenanthren 1 yl 2 [2
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