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3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine
Molecular Weight: 368
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Epub 2014 Jun 21
β-Lapachone 099.1 amine-Boc hydrochloride 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazineARQ 501, also known as beta lapachone, is a naphthoquinone compound derived from bark of Tabebuia sp., with antitumor, antibacterial, antifungal and antitrypanosomal activities. Beta lapachone exerts its anti tumor effect by indirect actions of inducing p53 independent apoptosis and cell cycle arrest mediated through altered activities of cell cycle control regulatory proteins; including down regulating retinoblastoma protein (pRB), a transcriptional
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