CB-839 H 298 109(4):360-4

109(4):360-4

NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells

11 nM and 180 nM for PDE5

blocks T-type calcium channels present in the efferent glomerular arterioles

CB-839 H 298 109(4):360-4Telaglenastat, also known as CB 839, an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Telaglenastat selectively and irreversibly inhibits glutaminase. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the