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4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
Smiles: O=C1NC2=CC=CC=C2N1C1CCN(CC2C=CC(=CC=2)C2=NC3=CC4NC=NC=4C=C3N=C2C2C=CC=CC=2)CC1
Solubility: DMSO 88 mg/mL (201
Molecular Weight: 168
Upadacitinib 1293 4-tetrahydroisoquinoline-3-carboxylic acid hydrochlorideUpadacitinib (ABT 494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT 494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT 494) is used in development for the treatment of several autoimmune disorders. Product information CAS Number: 1310726 60 3 Molecular Weight: 380. 37 Formula: C17H19F3N6O
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