GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 1138549-36-6

1138549-36-6

Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death

112(6):1839-44

74(1):49-56

GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 1138549-36-6GNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53