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Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells
158(6):1324-34
tolerability
UNC0379 was used at 10-30 µM in vitro assays
Ferrostatin-1 - Fer-1, Ferroptosis Inhibitor. CAS# 347174-05-4 size:2mg solid Hydroxychloroquine Destabilizes Phospho-S6 in HumanFerrostatin 1 (Fer 1), CAS No. 347174 05 4 , is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin induced ferroptosis in HT 1080 cells. Ferroptosis is a unique iron dependent form of nonapoptotic cell death triggered by the oncogenic RAS selective lethal small molecule erastin. Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemically, and genetically distinct
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