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C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25
and Jurkat) were quite sensitive to compound 2-induced killing
CCZ01048 TFA
Formula: C59H58ClN7O11
DL-TBOA Catalog No.:M18376-C C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25DL TBOA is a potent non transportable inhibitor of excitatory amino acid transporters with IC50s of 70 M, 6 M and 6 M for excitatory amino acid transporter 1 (EAAT1), EAAT2 and EAAT3, respectively. DL TBOA inhibits the uptake of [14C]glutamate in COS 1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 M and 5. 7 M, respectively. DL TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4. 4 M and 3. 2 M, respectively.
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