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FM-381 shows an apparent EC50 of 100 nM in a dose dependent BRET assay and blocks IL2 stimulated (JAK3/JAK1 dependent) STAT5 phosphorylation at 100 nM
OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells
and subsequently
BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs
Yadanzioside A 30458 FM-381 shows an apparent EC50Yadanziolide A, a quassinoid glycoside from Brucea javanica, has antitumor activity. Product information CAS Number: 95258 15 4 Molecular Weight: 684. 68 Formula: C32H44O16 Chemical Name: methyl (1R,2S,3R,6R,8S,9S,13S,14R,15R,16S,17R) 15,16 dihydroxy 9,13 dimethyl 3 [(3 methylbutanoyl)oxy] 4,10 dioxo 11 {[(2S,3R,4S,5S,6R) 3,4,5 trihydroxy 6 (hydroxymethyl)oxan 2 yl]oxy} 5,18 dioxapentacyclo[12. 5. 0. 0,. 0,. 0,]nonadec 11 ene 17 carboxylate Smiles:
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