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ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus
InChi: InChI=1S/C21H25ClN2O4S
InChiKey: DZHFTEDSQFPDPP-HWYNEVGZSA-L
2016 Jul 29
Diclofenac sodium (DSS) ARN-509 binds to AR inDiclofenac is a nonsteroidal anti inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX 1 and 2), thereby blocking the conversion of arachidonic acid to pro inflammatory proprostaglandins. This agent also may inhibit COX 2 mediated tumor angiogenesis. When inhibiting COX 2, Diclofenac may be effective in relieving
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