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Suppression of the clinical and cytokine response to endotoxin by RWJ-67657
InChiKey: JAMULYFATHSZJM-UHFFFAOYSA-N
After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC50 >10 μM
and 2-HG production in HT1080 and U87MG cells with IC50 < 0
AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 Suppression of the clinical andAZD6244, CAS No. 606143 52 6, (Selumetinib, ARRY 142886) is an orally active, highly potent and selective non ATP competitive MEK inhibitor, inhibiting MEK1 with an IC50 of 14 nM. In vitro cell viability inhibition screening of a tumor cell line panel found that cell lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244. Treatment of primary HCC cells with AZD6244 led to growth inhibition, caspase 3 and caspase 7
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