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1-6-2-4-7(5-3-6)11(8
AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q
is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2)
Smiles: OC(CNC1C=CC=CC=1)CN1C2=CC=C(Br)C=C2C2=CC(Br)=CC=C12
OTX015 - BET Inhibitor. CAS# 202590-98-5 size:2 mg solid 1-6-2-4-7(5-3-6)11(8OTX015, CAS No. 202590 98 5, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10 19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down regulation of c MYC expression, and show the synergistic anti proliferative effects in combination with ALK inhibitors in ALKpos