Sertraline Hydrochloride IN-1 robust PK/PD correlation and tumor

robust PK/PD correlation and tumor growth inhibition (TGI) in a U87MG mouse xenograft model

Chemical Name: 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide

1207360-89-1

Protective effects of Kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization

Sertraline Hydrochloride IN-1 robust PK/PD correlation and tumorSertraline, also known as , is a selective serotonin uptake inhibitor that is used in the treatment of depression. Sertraline is primarily a serotonin reuptake inhibitor (SRI) with a binding affinity towards the serotonin transporter of Ki=2. 8 nM or in that range. Sertraline is also a dopamine reuptake inhibitor, (<50 nmol L). However, this is not considered a tight binding, and this action is only 10% of its potency as a monoamine reuptake