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GSK-J4 could be a unique small molecule to allow selective pharmacological intervention across the JMJ family
4R)-4-hydroxy-6-oxooxan-2-yl]ethenyl]-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
Energy conversion efficiencies greater than 50% are achievable
5% is the 13-cis and less than 1% is the 9-cis with 94% being all-trans
RAS inhibitor Abd-7 Size:Contact [email protected] for quotation GSK-J4 could be a uniqueRAS inhibitor Abd 7, a potent RAS binding compound (Kd=51 nM), is a RAS effector protein protein interaction (PPI) inhibitor. RAS inhibitor Abd 7 interacts with RAS inside the cells, prevents RAS effector interactions and inhibits endogenous RAS dependent signaling. RAS inhibitor Abd 7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V. Product information CAS Number: 2351843 48 4 Molecular
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