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Solubility: DMSO: 29 mg/mL(197
Mice treated orally with 10 mg CZC24832 per kg body weight twice per day show a substantial decrease of bone and cartilage destruction (53% reduction by histopathological analysis) as well as of overall clinical parameters (38% reduction)
González-Corrochano R
InChi: InChI=1S/C30H32F6N4O2/c1-28(2
PF-CBP1 hydrochloride Size:2mg solid Solubility: DMSO: 29 mg/mL(197PF CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF CBP1 hydrochloride reduces LPS induced inflammatory cytokines expression (IL 1, IL 6 and IFN ) in primary macrophages. PF CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders,
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