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High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1
yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1)
and that both lobes are required for binding to receptor8
Smiles: NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Palbociclib-propargyl 314entane-1 5-diamine dihydrochloride High affinity and highly potentPalbociclib propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP 10. CP 10 shows a DC50 of 2. 1 nM for CDK6. Product information CAS Number: 2366269 23 8 Molecular Weight: 485. 58 Formula: C27H31N7O2 Chemical Name: 6 acetyl 8 cyclopentyl 5 methyl 2 ({5 [4 (prop 2 yn 1 yl)piperazin 1 yl]pyridin 2 yl}amino) 7H,8H pyrido[2,3 d]pyrimidin 7 one Smiles:
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