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InChi: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4
3-difluoroazetidin-1-yl)-2'
Beilstein J Org Chem
66-42-38(60)35(57)32(54)26(19-49)63-42)23-12-16-46(7)30(23)24(51)17-28-45(6)15-13-29(52)44(4
FM-479 11378 InChi: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4FM 479 is the negative control of FM 381 (HY 102046) and has no activity on JAK3 or other kinases. FM 381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM 381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600 fold selectivity over JAK1, JAK2 and TYK2, respectively. Product information CAS Number: 2226521 64 6 Molecular Weight: 442. 51 Formula: C25H26N6O2 Chemical Name: (2E) 2 cyano 3 (5 {3 cyclohexyl 10 methyl 3,
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