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22(17):5396-404
with an IC50 of 100 μM for S3I-201
PD0325901 was orally administrated to mice at 25 mg/kg once per day
Crenolanib decreases NSCLC cell viability
PCI-34051 - HDAC8 Inhibitor. CAS# 950762-95-5 B3i 22(17):5396-404PCI 34051, CAS No. 950762 95 5, is a potent and selective inhibitor of histone deacetylase 8 (HDAC8) with an IC50 ~10 nM. It displays >200 fold selectivity over other HDAC isoforms 1, 2, 3, 6 and 10. PCI 34051 has a unique mechanism of action involving PLCgamma1 activation and calcium induced apoptosis, and could offer benefits including a greater therapeutic index for treating T cell malignancies. PCI 34051 induces caspase dependent apoptosis in cell