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ITI-214 exhibited picomolar inhibitory potency for PDE1
Smiles: COC1C=C(NC2=NC3=CC=CC=C3N=C2NS(=O)(=O)C2C=C(C=CC=2)NC(=O)C(C)(C)N)C(Cl)=CC=1
2015 Jan 12
The Isotope labelled form of Febuxostat which is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase
Docetaxel (Trihydrate) Size:Solid 2 mg ITI-214 exhibited picomolar inhibitory potencyDocetaxel, also known as RP 56976, is a semi synthetic, second generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell cycle arrest at the G2 M phase and cell death. This agent also inhibits pro angiogenic factors such as vascular endothelial growth factor