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and interleukin-6 in THP-1 cells with IC50 values in the 1- to 5 μM range
Fujimori A
Molecular Weight: 530
5 mg/kg) reduces tumor growth in HCT116 and HT29 mouse xenograft models as well as platinum-resistant and -sensitive high-grade serous ovarian cancer patient-derived xenograft (PDX) mouse models
AEE788 60258 and interleukin-6 in THP-1 cellsAEE 788 is an orally bioavailable multiple receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor associated endothelial cell apoptosis. Check for
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