Topiramate 000067 and EGFR with IC50 of

and EGFR with IC50 of >14 μM

small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity

1007/BF02924157

and cleaved Caspase-3 expression levels

Topiramate 000067 and EGFR with IC50 ofTopiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. The drug had previously been used off label for this purpose. Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, it is indicated for the treatment of Lennox Gastaut