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DGAT1-IN-3 inhibits human DGAT-1 in CHOK1 cells with an EC50 of 0
Solubility: DMSO 68 mg/mL (199
10(4):268-72
1993 Dec 15
(R)-(+)-Etomoxir Sodium Salt rtine Maleate DGAT1-IN-3 inhibits human DGAT-1 inEtomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT 1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPAR.