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Discovery of BAF312 (Siponimod)
40-octakis(hydroxymethyl)-2
Smiles: CC1=NC=C(CO)C(COC)=C1O
4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor
J-113863 Size:Contact [email protected] for quotation Discovery of BAF312 (Siponimod)J 113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0. 9 nM and 5. 8 nM for human and mouse CCR1 receptors, respectively. J 113863 is also a potent antagonist of the human CCR3 (IC50 of 0. 58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J 113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF receptors. Anti inflammatory effect. Product information CAS Number: 353791 85 2 Molecular
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