CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM)
Oral administration of RDEA119 at 50 mg/kg on a once daily × 14 schedule leads to a 68% tumor growth inhibition (TGI) in human melanoma A375 tumor model
Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study
is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR)
PNU 22394 hydrochloride zinate CRT0044876 is a potent andProduct information CAS Number: 15923 42 9 Molecular Weight: 236. 74 Formula: C13H17ClN2 Chemical Name: (6R) 6 methyl 1H,2H,3H,4H,5H,6H azepino[4,5 b]indol 6 ium chloride Smiles: [Cl ]. C[N@H+]1C2=CC=CC=C2C2CCNCCC1=2 InChiKey: SAIGGEUWSYESTR UHFFFAOYSA N InChi: InChI=1S C13H16N2. ClH c1 15 12 5 3 2 4 10(12)11 6 8 14 9 7 13(11)15; h2 5,14H,6 9H2,1H3; 1H Technical Data Appearance: Solid Power Purity: 98% (or refer to the Certificate of Analysis)