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BSJ-03-123 is a phthalimide-based degrader that exploits protein-interface determinants to achieve proteome-wide selectivity for the degradation of cyclin-dependent kinase 6 (CDK6)
InChiKey: TXLVFISHOZJIQV-WYIJURDSSA-N
CHIR99021 (2 mg/kg) given once
Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer's disease
Sunitinib D10 fenone D7 Hydrochloride BSJ-03-123 is a phthalimide-based degraderSunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFR, respectively. Sunitinib, an ATP competitive inhibitor, effectively inhibits autophosphorylation of Ire1 by inhibiting autophosphorylation and consequent RNase activation. Product information CAS Number: 1126721 82 1 Molecular Weight: 408. 54 Formula: C22H27FN4O2 Chemical
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