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Smiles: COC1=CN=C(NS(=O)(=O)C2C=CC(N)=CC=2)N=C1
MRZ) is a novel marine derived proteasome inhibitor which inhibits CT-L β5
Formula: C28H28ClNO4S
Kuninaka Y
Tazemetostat trihydrochloride - CAS# 1403255-00-4 NH-C8-NH2 hydrochloride Smiles: COC1=CN=C(NS(=O)(=O)C2C=CC(N)=CC=2)N=C1Tazemetostat trihydrochloride (EPZ 6438 trihydrochloride) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat trihydrochloride inhibits the activity of human polycomb repressive complex 2 (PRC2) containing wild type EZH2 with a Ki of 2. 5 nM. Tazemetostat trihydrochloride inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat trihydrochloride inhibits rat EZH2 with an IC50 of 4
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