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Antagonism of sigma-1 receptors blocks compulsive-like eating
It Inhibits AGEs-mediated increase of Aβ-metabolism-related proteins and downregulates AGEs-mediated increase of pro-inflammatory cytokines in the hippocampus
PubMed PMID: 23865465
PubMed PMID: 25389405
DZ2002 Catalog No.:M8502-2 Antagonism of sigma-1 receptors blocksDZ 2002 is a potent reversible inhibitor of S adenosyl L homocysteine hydrolase (SAHH). DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types and would be a potential drug for the treatment of systemic sclerosis. Product information CAS Number: 33231 14 0 Molecular Weight: 251. 24