ONX 0801 trisodium vedilol metabolite 4-Hydroxyphenyl Carvedilol An FGFR3/MYC positive feedback loop

An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

specifically targeting key stem cell subpopulations of AML

CAS Number: 528-63-2

2018 Oct 18

ONX 0801 trisodium vedilol metabolite 4-Hydroxyphenyl Carvedilol An FGFR3/MYC positive feedback loopONX 0801 (BGC 945) trisodium is a thymidylate synthase (TS) inhibitor, targeted to folate receptoroverexpressing tumors. Product information CAS Number: 1097638 00 0 Molecular Weight: 713. 58 Formula: C32H30N5Na3O10 Chemical Name: trisodium (2R) 2 [(4S) 4 carboxylato 4 [(4 {[(6S) 2 (hydroxymethyl) 4 oxo 3H,4H,6H,7H,8H cyclopenta[g]quinazolin 6 yl](prop 2 yn 1 yl)amino}phenyl)formamido]butanamido]pentanedioate Smiles: [Na+].[Na+].[Na+].