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Non-GLP preclinical assessment of cardiovascular effects and genotoxicity does not reveal any issues that would prevent further development
Smiles: OC1C=COC=1C=O
Smiles: CC1OC2=C(O)C(=CC=C2C=1C(=O)C1=CC(OC)=C(OC)C(=C1)OC)OC
A total of 102 (84%) of the 122 isolates are negative for indole production
JAK1-IN-7 18136 Non-GLP preclinical assessment of cardiovascularJAK1 IN 7 is a Janus associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti inflammatory effect. Product information CAS Number: 2241039 81 4 Molecular Weight: 599. 65 Formula: C28H31F2N7O4S Chemical Name: (2R) N (3 {5 fluoro 2 [(2 fluoro 3 methanesulfonylphenyl)amino]pyrimidin 4 yl} 1H indol 7 yl) 3 methoxy 2 (4 methylpiperazin 1 yl)propanamide Smiles:
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