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and HER3 activation in medulloblastoma cell lines
13: 433-443
407(6802):395-401
2009 May 8
Voreloxin - CAS# 175414-77-4 Size:Solid 2 mg and HER3 activation in medulloblastomaVoreloxin, also known as SNS 595 or Vosaroxin, is a s mall molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site specific manner and blocks the re ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53 independent apoptosis. This agent shows a
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