IM-250 isantherin A is more convenient to incorporate

is more convenient to incorporate the nitro group after deprotection lithium aluminum hydride

TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling

and pathway-based profiling establish the selectivity of JNK-IN-8 for JNK and suggests that the compound will be broadly useful as a pharmacological probe of JNK-dependent signal transduction

Vidya Iyer

IM-250 isantherin A is more convenient to incorporateIM 250 not only reduces the duration of disease symptoms or time to healing but also prevents recurrent disease in guinea pigs. Treatment of recurrent infections reduces the frequency of recurrences and viral shedding, and, unlike nucleosidic drugs, IM 250 remains effective for a time after cessation of treatment. Hence, IM 250 has advantages over standard of care therapies and represents a promising therapeutic for chronic HSV infection, including