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IWP-O1 - CAS# 2074607-48-8 size:10mg solid with IC50s of 370 nM

SKU: 89322926795

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Description

with IC50s of 370 nM

Smiles: [O-][N+](=O)C1=CC(/C=N/NC(=O)C2C=C(O)C=C(O)C=2)=CC=C1O

InChi: InChI=1S/C28H30Cl3N7O5S/c1-37(2)10-4-7-24(39)33-19-5-3-6-20(15-19)44(42

axonal loss and APP positivein spinal cord of Fasudil-treated mice via p

IWP-O1 - CAS# 2074607-48-8 size:10mg solid with IC50s of 370 nMIWP O1, CAS No. 2074607 48 8, is highly potent Porcn inhibitor, The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. IWP O1 has an EC50 value of 80pM in a cultured cell reporter assay of Wnt signaling. Additionally, IWP O1 has significantly improved metabolic stability over our previously reported Porcn inhibitors. Product information CAS

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