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AG-490 (50 μM) can induce apoptosis of imatinib-resistant BaF3 cells expressing T315I and E255K mutants of Bcr-Abl
such as NODI and NOD2
CAS Number: 910462-43-0
GSK 3117391A
Sunitinib - CAS# 557795-19-4 Size:Solid 10 mg AG-490 (50 μM) can induceSunitinib free base is an oral, small molecule, multi targeted receptor tyrosine kinase (RTK) inhibitor. Sunitinib malate salt was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). The simultaneous inhibition of these targets therefore reduces tumor
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