PT 1 Catalog No.:M23080-C 2-a]pyridin-3-yl)-2-thiazolamine

2-a]pyridin-3-yl)-2-thiazolamine

Smiles: C1CC(CCN1)NC1=CC=CC(=N1)C1=CN=C2C=CC=CN21

Chemical Name: 9a

is a novel and selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2

PT 1 Catalog No.:M23080-C 2-a]pyridin-3-yl)-2-thiazolaminePT 1 is a selective activator of AMPK with EC50 value of 0. 3 M for AMPK 111 . AMP activated protein kinase (AMPK) is serine threonine protein kinase that involved in cellular energy homeostasis and acts as an energy sensor. AMPK is a heterotrimer and increases ATP generation . PT 1 is a selective AMPK activator. PT1 activated human AMPK 1394, AMPK 2398 and AMPK(111) with EC50 values of 8, 12 and 0. 3 M, respectively. PT1 exhibited maximum activity